We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other |

Reliability of the Methacholine (Mecholyl) Test Variation in Results When Performed upon the Same Patient by Different Examiners

AMA Arch NeurPsych. 1958;79(5):585-589. doi:10.1001/archneurpsyc.1958.02340050113014.
Text Size: A A A
Published online


Introduction  In 1950 Funkenstein, Greenblatt, and Solomon1 published their work with the epinephrine-methacholine (Mecholyl) test and its relation to prognosis with electroshock therapy (EST). In 19522 they further reported that prognosis could be predicted with the use of methacholine alone; i. e., those patients whose systolic blood pressure did not return to a basal level 25 minutes after injection with methacholine (a Type-6 curve) had a good prognosis with EST, as did those in whom the drug produced a chill and either relieved or precipitated severe anxiety. In further work 3,4 these authors felt that the type of response was perhaps related to the secretion of epinephrine-like and arterenol-like substances—the former associated with "anger in" and failure to establish homeostasis, the latter with "anger out" and the return of the systolic blood pressure to at least the preexisting basal level. Further acceptance of the above assumption was brought


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.