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February 1951, Vol 65, No. 2 >
Other | February 1951

CLINICAL AND PHYSIOLOGICAL STUDIES IN A CASE OF MYOKYMIA

H. HOLLAND DE JONG, M.D.; IRVING A. MATZNER, M.D.; ARTHUR A. UNGER, M.D.
AMA Arch NeurPsych. 1951;65(2):181-188. doi:10.1001/archneurpsyc.1951.02320020053005.
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KNY1 IN 1888, reported a clinical case of a condition which he termed "myoclonus fibrillaris multiplex." The patient was a man aged 50 whose disease was characterized by the gradual onset of cramps and fasciculations. Both conditions occurred in the gastrocnemius muscles, and fasciculations alone were present in the peroneus, rectus abdominis, deltoid, biceps and interosseus muscles. In 1895 Schultze1 recorded the following case of a disease which he named "myokymia." A man aged 21 was seized with painful cramps in his lower limbs, which, when moved actively or passively, went into spasm. On other occasions brief painful contractions occurred, with tonic plantar flexion of the toes and extension of the great toe. The muscles of the calves and thigh and selected muscle groups of the chest and arms exhibited a constant, sinuous, local fasciculating movement. The feet and legs were bathed in perspiration. Of these two cases,

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