Knowledge of the presence of characteristic roentgenographic changes in the skull of patients with tuberous sclerosis has been a fairly recent addition to the diagnostic criteria of this disease entity. In 1924 Marcus1 described the roentgenogram in a case of tuberous sclerosis, as follows:
In several places within the cranium were calcified areas the size of a bean or pea, with layers of "chalk shale." Most such areas were located in the middle fossa on the left side, but several were visible in the parietal regions.
Dalsgaard-Nielsen stated that Marcus' case is the first published instance of tuberous sclerosis with roentgenographically discovered calcification in the cerebrum. In 1935 Dalsgaard-Nielsen2 published the following description of the calcifications noted in roentgenograms of the skull of a 14 year old boy with convulsive seizures and adenoma sebaceum.
The shape of the cranium is normal. The sella turcica is small but otherwise