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Arch NeurPsych. 1945;53(3):199-204. doi:10.1001/archneurpsyc.1945.02300030036005.
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Knowledge of the presence of characteristic roentgenographic changes in the skull of patients with tuberous sclerosis has been a fairly recent addition to the diagnostic criteria of this disease entity. In 1924 Marcus1 described the roentgenogram in a case of tuberous sclerosis, as follows:

In several places within the cranium were calcified areas the size of a bean or pea, with layers of "chalk shale." Most such areas were located in the middle fossa on the left side, but several were visible in the parietal regions.

Dalsgaard-Nielsen stated that Marcus' case is the first published instance of tuberous sclerosis with roentgenographically discovered calcification in the cerebrum. In 1935 Dalsgaard-Nielsen2 published the following description of the calcifications noted in roentgenograms of the skull of a 14 year old boy with convulsive seizures and adenoma sebaceum.

The shape of the cranium is normal. The sella turcica is small but otherwise


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